The series follows city journalist Ozzie Graham, played by Wyatt Cenac, who travels to Beacon, New York to write a piece on a support group called "StarCrossed," who are survivors of alien encounters. The abductees are stereotypical tin-foil-hat folks. Although skeptical at first, Ozzie realizes the truth of the group's claims when he begins to recall similar experiences. Ozzie eventually quits his job and moves to Beacon to further investigate the town's strange occurrences, as well as resolve issues in his past related to his possible abduction.

As the series progresses, Ozzie gradually learns that his employer, Jonathan Walsh, is a reptilian (alien) in disguise. Jonathan, who has considered him a friend since he abducted the young Ozzie, explains that the Trinity Federation, an alliance among three races of extra-terrestrials (greys, whites, and reptilians), was sent many years ago to conquer Earth under reptilian leadership. However, in his time on Earth, Jonathan has developed sympathy for humans and wants to expose the truth about the invasion, so he hopes to persuade his alien coworkers and the humans he calls friends to help.